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Discovery Medicine / No 038


Bioterror, Agroterror, and New Diseases

Abstract: As research techniques and biotechnology advance, the risk for potential bioterrorism increases due to the ease of creating or modifying virulent pathogenic microorganisms. In addition, the destruction of natural habitats to a host of animals and microbial species that are normally sequestered in these areas may bring about new diseases to humans. ... Read more

Molecular and Genetic Profiling in Human Gliomas

Abstract: Glioblastoma multiforme is the most aggressive fatal brain tumor with a median survival of about a year after diagnosis. The current available treatment options only marginally improve patient outcome. The complexity and heterogeneity of the disease pose an extensive challenge to the development of novel therapeutic agents. Through molecular and genetic profiling, it has been possible to both identify mechanisms of disease progression and its therapeutic resistance. This paper highlights the significance of these advances. ... Read more

Magnetic Nanoparticles: Prospects in Cancer Imaging and Therapy

Abstract: Nanotechnology based on the use of submicronic particles of inorganic and/or organic origin has the potential to revolutionalize the clinical management of cancer; the possibility of real time monitoring of disease progression and effects of therapy is now real. Especially, iron oxide super paramagnetic nanoparticles have shown clinical utility in cancer imaging and drug delivery and some formulations are now FDA-approved for use in the clinic. The prospects of magnetic nanoparticles in cancer imaging and treatment are reviewed. ... Read more

New Hope for Diabetics: Adult Blood Stem Cells Can Make Insulin

Abstract: Human blood stem cell-derived insulin-producing cells can be easily isolated from autologous blood based on their unique phenotype. They act as pancreatic islet beta-cell progenitors, as demonstrated by authentic insulin production and homing to diabetic pancreatic islets. Clinical application of these autologous blood-derived insulin-producing cells holds great promise for diabetic treatment. ... Read more

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